JAK1 (phospho Y1034 + Y1035); p-JAK1 (phospho Y1034 + Y1035); JAK 1; JAK 1A; JAK 1B; JAK-1; JAK1; JAK1_HUMAN; JAK1A; JAK1B; Janus kinase 1 (a protein tyrosine kinase); Janus kinase 1; JTK3; Tyrosine protein kinase JAK 1; Tyrosine protein kinase JAK1; Tyrosine-protein kinase JAK1.
产品类型
磷酸化抗体
研究领域
肿瘤 细胞生物 免疫学 染色质和核信号 信号转导 细胞凋亡 激酶和磷酸酶 表观遗传学
抗体来源
Rabbit
克隆类型
Polyclonal
交叉反应
Human, (predicted: Mouse, Rat, Pig, Cow, )
产品应用
WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=2μg /Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
133kDa
细胞定位
细胞膜
性 状
Liquid
浓 度
1mg/ml
免 疫 原
KLH conjugated Synthesised phosphopeptide derived from human Jak1 around the phosphorylation site of Tyr1034 + Tyr1035:KE(p-Y)(p-Y)TV
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Subunit: Interacts with FER. Interacts with IL31RA, IFNAR2, JAKMIP1 and SHB.
Tissue Specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Contains 1 FERM domain. Contains 1 protein kinase domain. Contains 1 SH2 domain.