Pritelivir普瑞利韦,348086-71-5

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Pritelivir

CAS No. : 348086-71-5

MCE 国际站：Pritelivir

产品活性：Pritelivir (AIC316) 是一种病毒解旋酶-引物酶复合物 (helicase-primase complex) 抑制剂，在体外和单纯疱疹病毒 (HSV) 感染的动物模型中均具有抗病毒活性。Pritelivir 对 1 型和 2 型单纯疱疹病毒 (HSV-1 和 HSV-2) 具有活性，对 HSV1-2 的 IC₅₀ 为 0.02 μM。

研究领域：Anti-infection

作用靶点：HSV

In Vivo: Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase-primase enzyme complex.
Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis.
Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS.

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