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- 技术资料
- CAS号：
348086-71-5
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥364.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥164.0 |
| 规格： | 5mg | 产品价格： | ￥330.0 |
| 规格： | 10mg | 产品价格： | ￥462.0 |
| 规格： | 25mg | 产品价格： | ￥735.0 |
| 规格： | 50mg | 产品价格： | ￥984.0 |
| 规格： | 100mg | 产品价格： | ￥1584.0 |
| 规格： | 500mg | 产品价格： | ￥3896.0 |
Product Introduction
Bioactivity
| 名称 | Pritelivir |
| 描述 | Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM). |
| 激酶实验 | In vitro procaspase-3 activation: Procaspase-3 is expressed and purified in Escherichia coli. Various concentrations of PAC-1 are added to 90 μL of a 50 ng/mL of procaspase-3 in caspase assay buffer in a 96-well plate, The plate is incubated for 12 hours at 37 °C. A 10 μL volume of a 2 mM solution of caspase-3 peptidic substrate acetyl Asp-Glu-Val-Asp-p-nitroanilide (Ac-DEVD-pNa) in caspase assay buffer is then added to each well. The plate is read every 2 minutes at 405 nm for 2 hours in a Spectra Max Plus 384 well plate reader. The slope of the linear portion for each well is determined, and the relative increase in activation from untreated control wells is calculated. |
| 体外活性 | 在小鼠和大鼠致死性散播疱疹发病模型、小鼠带状疱疹样皮肤疾病扩散模型中,BAY57-1293（0.5/15 mg/kg,p.o.）均具有较强的抗病毒活性.在小鼠眼疱疹模型中也是如此. |
| 体内活性 | BAY57-1293剂量依赖的直接抑制病毒解旋酶-引发酶复合物的ATPase活性。BAY57-1293对耐阿昔洛韦的单纯疱疹病毒突变体也有明显的抗病毒活性。在绿猴肾细胞中,其还可降低1型单纯性疱疹病毒引起的Aβ和P-tau。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 24.5 mg/mL (60.87 mM), Solution. 10% DMSO+90% Saline : < 24.5 mg/mL (60.87 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 245 mg/mL (608.71 mM), Sonication is recommended. |
| 关键字 | virus | viral | RNASynthesis | RNA Synthesis | Pritelivir | primase | Inhibitor | inhibit | HSV-2 | HSV-1 | HSV | Herpes simplex virus | herpes | helicase primase | helicase | DNASynthesis | DNA Synthesis | complex | AIC-316 | AIC 316 |
| 相关产品 | Oxyresveratrol | Carbazole | Hexane-1,6-diol | Guanidine hydrochloride | 1,4-Naphthoquinone | 5-Fluorouracil | Usnic Acid | Adenine hemisulfate | Erythromycin thiocyanate | Adenine | L-Lysine | Thymidine |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | ReFRAME Related Library | Anti-Aging Compound Library | Anti-Viral Compound Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Human Metabolite Library | Anti-Cancer Drug Library |
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￥164 - 3896
