Resminostat,864814-88-0

价格￥1100 - 3933

品牌MedChemExpress(MCE)
产地美国
货号HY-14718
更新日期2025年12月05日

MedChemExpress LLC

品牌商

14 年钻石会员

详细信息
技术资料

保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
英文名：
RAS2410; 4SC-201
库存：
货期：1-2天
供应商：
MedChemExpress LLC
CAS号：
864814-88-0
规格：
10 mM * 1 mL/5 mg/10 mg/25 mg

规格：	10 mM * 1 mL	产品价格：	￥1210.0
规格：	5 mg	产品价格：	￥1100.0
规格：	10 mg	产品价格：	￥1800.0
规格：	25 mg	产品价格：	￥3933.0

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Resminostat

CAS No. : 864814-88-0

MCE 国际站：Resminostat

产品活性：Resminostat (RAS2410; 4SC-201) 是一种有效的 HDAC1，HHDAC3 和 HDAC6 抑制剂，IC₅₀ 值分别为 42.5，50.1，71.8 nM，同时对 HDAC8 有较弱的抑制作用，IC₅₀ 值为 877 nM。

研究领域：Cell Cycle/DNA Damage | Epigenetics

作用靶点：HDAC

In Vitro: Resminostat (RAS2410; 4SC-201; 5 μM) induces histone acetylation in myeloma cells. Resminostat hydrochloride displays a substrate competitive binding mode with a mean K_i value of 27 nM. Resminostat hydrochloride (5 μM) induces histone hyperacetylation in myeloma cells. Resminostat inhibits cell growth, induces apoptosis and inhibits MM cell proliferation. Resminostat (5 μM) also modulates expression of bcl-2 family proteins and inhibits Akt pathway signalling downstream of Akt. Resminostat exerts synergistic activity against myeloma cells when combined with common and new anti-myeloma agents.
Resminostat inhibits cell growth in head and neck squamous cell carcinoma cell lines, with IC₅₀s ranging from 0.775 μM to 1.572 μM (IC₅₀ for SCC25: 0.775 μM; CAL27: 1.572 μM; and FaDu: 0.899 μM). Resminostat (1.25 and 2.5 μM) has a synergistic effect with irradiation on HNSCC cell lines. Resminostat in combination with cisplatin induces a downregulation of survivin. However, Resminostat shows no effect on Mcl-1 and p-AKT expression.
Resminostat reduces viability of HCC cells with the co-treatment of AZD-2014, with IC₅₀s ranging from 0.89 ± 0.12 μM to 0.07 ± 0.01 μM.