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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
GS-4224; PD-1/PD-L1-IN 7
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2374856-75-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4656.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1234.0 |
| 规格： | 5 mg | 产品价格： | ￥3060.0 |
| 规格： | 10 mg | 产品价格： | ￥4860.0 |
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Evixapodlin
CAS No. : 2374856-75-2
MCE 国际站：Evixapodlin
产品活性：Evixapodlin (GS-4224) 是一种人 PD-1/PD-L1 蛋白/蛋白相互作用的抑制剂，IC50 为 0.213 nM。Evixapodlin 具有抗癌和抗病毒功能。
研究领域：Immunology/Inflammation | Anti-infection
作用靶点：PD-1/PD-L1 | HBV
In Vitro: Evixapodlin (compound 139) enhances IFN-γ and Granzyme B Production in chronic hepatitis B (CHB) CD8+ T Cells and CD4+ T Cells. Evixapodlin also enhances the frequency of GrB+ cells among HBV-specific CD8+ and CD4+ T cells. The ability of Evixapodlin to enhance the antiviral functions of HBV-specific CD8+ and CD4+ T cells in vitro is comparable to those of Durvalumab.
In Vivo: Evixapodlin (Compound 139; 10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment shows >90% PD-L1 target occupancy (TO) on the tumor cells. Evixapodlin significantly inhibits tumor growth in a human PD-L1 expressing MC38 mouse colorectal tumor model.
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