- 询价
- MedChemExpress(MCE)
- 美国
- HY-106345
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Please store the product under the recommended conditions in the Certificate of Analysis.
- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- CAS号：
892494-07-4
- 规格：
询盘
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
ILS-920
CAS No. : 892494-07-4
MCE 国际站：ILS-920
产品活性：ILS-920 是一种非免疫抑制性雷帕霉素类似物，具有有效的神经保护活性。ILS-920 选择性结合亲免蛋白 FKBP52 和 L 型电压门控钙通道 (VGCC) 的 β1 亚基。ILS-920 对 FKBP52 的选择性是 FKBP12 的 200 倍。ILS-920 可大大降低了免疫抑制活性。
研究领域：Apoptosis | Immunology/Inflammation | Autophagy | Neuronal Signaling | Membrane Transporter/Ion Channel
作用靶点：FKBP | Calcium Channel
In Vitro: ILS-920 promotes neuronal survival and stimulates neurite outgrowth with potent neurotrophic activities in cortical neuronal cultures.
ILS-920 can inhibit L-type Ca2+ channels in rat hippocampal neurons and F-11 dorsal root ganglia (DRG)/neuroblastoma cells. ILS-920 can protect neurons from Ca2+-induced cell death by modulating Ca2+ channels and promote neurite outgrowth via FKBP52 binding.
In Vivo: In a transient middle cerebral artery occlusion (tMCAO) model of ischemic stroke, ILS-920, administered 4 h postocclusion at 10 and 30 mg/kg, significantly reduces infarct volume by 24% and 23% in 72 h, respectively, and robustly enhances functional recovery measured by improvement in neurological deficits.
相关产品：Rapamycin | Thapsigargin | Ionomycin | Everolimus | L-Ascorbic acid | Tacrolimus | Minocycline hydrochloride | Verapamil | 2-Aminoethyl diphenylborinate | Rimiducid | Acetylcholine chloride | GSK1016790A | Shield-1 | AP20187 | Nifedipine | Fasudil Hydrochloride | Ebselen | FKBP12 PROTAC dTAG-13 | Halofuginone | Tetrandrine | Carbamazepine | Ruthenium red | CDN1163 | ISX-9 | Gabapentin | SAFit2 | TPC2-A1-N
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验A Review of Three-Dimensional Printing in Tissue Engineering. Tissue Engineering Part B: Reviews. 22(4):298-310. http://dx.doi.org/10.1089/ten.teb.2015.0464 3.Langer R, Vacanti J. 1993. Tissue engineering. Science. 260(5110):920-926. http://dx.doi.org/10
,R3,R4,R5 7 5.251 1-Butene(1-丁烯-3-炔) 5.5 R4 8 5.323 trans-2-Butene(反-2-丁烯) 0.88 R3,R4,R5 9 5.398 1-Butyne(1-丁炔) 8.07 R4 10 5.548 cis-2-Butene(顺-2-丁烯) 3.72 R3,R4,R5 11 5.950 1,3-Butadinene(1,2-丁二烯) 10.85 R3,R4,R5 12 6.182 3-Methyl-1-butene
......... 10 ml 50 ml Succinate (20%). 2 ml 10 ml MSG (10%) ...... 2 ml 10 ml Glucose (40%) .. 1 ml 5 ml MgSO4 (0.1 M) .. 1 ml 5 ml CaCl2 (0.5 M) .. 200 ul 1 ml 1000X vitamins . 200 ul 1 ml Water .......... 184 ml 920 ml Omit
技术资料暂无技术资料 索取技术资料
