CLEFMA,1246964-32-8

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CLEFMA

CAS No. : 1246964-32-8

MCE 国际站：CLEFMA

产品活性：CLEFMA 是一种具有抗肿瘤活性的姜黄素。CLEFMA 抑制肿瘤生长与 NF-κB 调节的抗炎和抗转移作用有关。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity.
CLEFMA inhibits the viability of H441 and A549 cells, with IC₅₀s of 6.4 and 8.9 μM, respectively.
CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells.
CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells.
CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner.

In Vivo: CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model.
CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue.

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