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-20°C, sealed storage, away from moisture
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货期：1-2天
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- CAS号：
2136246-72-3
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1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥3800.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥9500.0 |
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MD-222
CAS No. : 2136246-72-3
MCE 国际站：MD-222
产品活性：MD-222 是一种首创的高效的基于 PROTAC 的 MDM2 降解剂。MD-222 由 Cereblon 和 MDM2配体组成。MD-222 诱导 MDM2 蛋白快速降解并激活细胞中的野生型 p53。MD-222 具有抗癌作用。
研究领域：Apoptosis | PROTAC | Metabolic Enzyme/Protease
作用靶点：MDM-2/p53 | PROTACs | E1/E2/E3 Enzyme
In Vitro: MD-222 (1-30 nM; 1-2 hours) treatment shows very effective in reducing the levels of MDM2 protein and increasing the levels of p53 in a time- and dose-dependent manner in RS4;11 and RS4;11/IRMI-2 cells.
MD-222 (30-100 nM; 6 hours) is effective in increasing the expression of several p53-targeted genes, such as MDM2, CDKN1A, and PUMA in RS4;11 cells, indicating strong activation of p53.
MD-222 (4 days) shows cell growth inhibitory activity in RS4;11 cells with an IC50 of 5.5 nM, and has no effect on RS4;11/IRMI-2, MDA-MB-231 and MDA-MB-468 cells.
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文献和实验C 10 H 15 NO 5 S 为分子量 261.3 ，白色针状结晶的化合物。对水的溶解度为 1.25g/ml （ 20 ℃）。广泛用作水生动物麻醉剂以代替氨基甲酸酯及硫酸镁等。最小有效量虽因动物而异，但将动物放入约 1/2000 至 1/3000 浓度的淡水或海水溶液中，可使之麻醉。
MD + QM Correlations with Tryptophan Fluorescence Spectral Shifts and Lifetimes
Principles behind quenching of tryptophan (Trp) fluorescence are updated and extended in light of recent 100-ns and 1-μs molecular dynamics (MD) trajectories augmented with quantum mechanical (QM) calculations that consider electrostatic
linli_1986 有谁做过乳腺癌细胞MBA-MD-231细胞的生长曲线的吗？对数期是在第几天啊？ freecell http://202.194.11.26:8001/xwlw/document?RecordNo=2765&ColumnName=FREETEXT_URL&MultiNo=0&issource=yes&type=bin&channelid=65373 消失一会儿 http
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