MK2-IN-3,724711-21-1

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MK2-IN-3

CAS No. : 724711-21-1

MCE 国际站：MK2-IN-3

产品活性：MK2-IN-3 是一种有效和选择性的 MAPKAP-K2 (MK-2) 抑制剂，IC₅₀ 值为 8.5 nM。MK2-IN-3 对 MK-3，MK-5，ERK2，MNK1，p38a (IC₅₀=0.21, 0.081, 3.44, 5.7, >100 μM) 和 MSK1，MSK2，CDK2，JNK2，IKK2 (IC₅₀>200 μM) 表现出良好的选择性。MK2-IN-3 可以减少 U937 细胞和体内 TNFα 的产生。

研究领域：MAPK/ERK Pathway

作用靶点：MAPKAPK2 (MK2)

In Vitro: MK2-IN-3 (compound 16) inhibits MK-2 and TNFα production in U937 cells, with IC₅₀s of 8.5 nM and 4.4 μM, respectively.

In Vivo: MK2-IN-3 (compound 16) (20 mg/kg; a single p.o. before LPS challenge) inhibits 20% TNFα production in rat LPS (rLPS) model.

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