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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
polypeptide, sealed storage, away from moisture
- 英文名：
GAP-134 Hydrochloride; ZP 1609 Hydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
943133-81-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1650.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥681.0 |
| 规格： | 5 mg | 产品价格： | ￥1500.0 |
| 规格： | 10 mg | 产品价格： | ￥2500.0 |
| 规格： | 25 mg | 产品价格： | ￥5000.0 |
| 规格： | 50 mg | 产品价格： | ￥7500.0 |
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Danegaptide Hydrochloride
CAS No. : 943133-81-1
MCE 国际站：Danegaptide Hydrochloride
产品活性：Danegaptide Hydrochloride (GAP-134 Hydrochloride) 是一种有效的，选择性的，具有口服活性的 gap-junction 修饰剂，具有抗心律不齐的作用。
研究领域：Cytoskeleton
作用靶点：Gap Junction Protein
In Vitro: Danegaptide (GAP-134, compound 9f; 0.01 nM-100 μM) dose dependently reduces dye uptake in cultured C6 glioma cells in a manner.
In Vivo: Danegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl2 model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl2.
?Danegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles.
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文献和实验Guanidine Hydrochloride Purification of Proteins From SDS
Pepstatin A (2.0 mg/ml)10 ml Leupeptin (1.0 mg/ml)10 ml Aprotinin (5.0 mg/ml)(Protease Inhibitor Cocktail Sigma #P8340)Denaturation Buffer6 M guanidine hydrochloride 57.3 g G-HCl20 mM Hepes 7.9 2 ml 1M Hepes pH 7.910 mM KCl 0.074 g KCl0.5 mM DTT 100 ml 0.5 M
Guanidine Hydrochloride Purification of Proteins From SDS PAGE
(Sigma #P7626) 10 ml Pepstatin A (2.0 mg/ml) 10 ml Leupeptin (1.0 mg/ml) 10 ml Aprotinin (5.0 mg/ml) (Protease Inhibitor Cocktail Sigma #P8340) Denaturation Buffer 6 M guanidine hydrochloride 57.3 g G-HCl 20 mM Hepes 7.9 2 ml 1M Hepes pH 7.9 10 mM
Packed column subcritical and/or supercritical fluid chromatography (p-sub or pSFC) has been used as a powerful chiral separation technique, whereby a mobile phase produces low viscosity, a high diffusion coefficient, and a solvating power. P
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