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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
BMS-790052; EBP 883
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1009119-64-5
- 规格：
10 mM * 1 mL/500 mg/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1057.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥ |
| 规格： | 1 mg | 产品价格： | ￥295.0 |
| 规格： | 5 mg | 产品价格： | ￥650.0 |
| 规格： | 10 mg | 产品价格： | ￥950.0 |
| 规格： | 50 mg | 产品价格： | ￥3800.0 |
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Daclatasvir
CAS No. : 1009119-64-5
MCE 国际站：Daclatasvir
产品活性：Daclatasvir (BMS-790052) 是一种有效的口服活性 HCV NS5A 蛋白抑制剂，多种 HCV 复制子基因型的 EC50 范围为 9-146 pM。Daclatasvir 也是有机阴离子转运多肽 1B (OATP1B) 和 OATP1B3 抑制剂，IC50 分别为 1.5 μM 和 3.27 μM。
研究领域：Anti-infection
作用靶点：HCV
In Vitro: Daclatasvir (BMS-790052) demonstrates potent inhibitory activity towards all genotypes tested, with EC50 values ranging from 9 pM to 146 pM. Daclatasvir inhibits HCV replicon genotype 1a, 1b, 2a, 3a, 4a and 5a with EC50 values of 50 pM, 9 pM, 71 pM, 146 pM, 12 pM and 33 pM, respectively. Daclatasvir is a potent inhibitor of the JFH-1 genotype 2a infectious virus that replicates in cell culture (EC50=28 pM). Daclatasvir (BMS-790052) binds tightly to NS5A33-202 and NS5A26-202 with Kds of 8 nM and 210 nM, respectively.
In Vivo: Daclatasvir (BMS-790052; 30 mg/kg; oral administration; daily; for 27 days) treatment reduces serum HCV RNA titers very rapidly by ~1.5 log10 at day 3.
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