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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
2041072-41-5
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥1870.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥923.0 |
| 规格: | 5 mg | 产品价格: | ¥2200.0 |
| 规格: | 10 mg | 产品价格: | ¥3900.0 |
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ICCB280
CAS No. : 2041072-41-5
MCE 国际站:ICCB280
产品活性:ICCB280 是一种有效的 C/EBPα 诱导剂。ICCB280 通过激活 C/EBPα 并影响其下游靶点 (例如 C/EBPε ,G-CSFR 和 c-Myc),具有抗白血病特性,包括终末分化,增殖停滞和凋亡。
研究领域:Apoptosis
作用靶点:Apoptosis
In Vitro: ICCB280 (0.1-50 μM; 48 h) suppresses the HL-60 cell growth, with an IC50 of 8.6 μM.
ICCB280 (10 μM; 2-8 d) increases the C/EBPα expression (mRNA and protein) and modulates its target genes in HL-60 cells.
ICCB280 (10 μM; 7 d) induces granulocytic differentiation and subsequent apoptosis in HL-60 cells.
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文献和实验LABELING GIZZARD MYOSIN WITH IATR (MHC AND 17KD MLC)
). Procedure 1.Thaw appropriate volume of frozen gizzard myosin to obtain 3-5 mg. 2.Dialyze against buffer 1 overnight to remove residual ammonium sulfate. 3.Clarify myosin solution at 20,000 rpm,4℃,for 30 min in a 50Ti rotor. 4.Dilute 20μl myosin with 400μ
, mouse (12) AACCACCGCCCUCCGUGCA HL-5 and 293 Cyclin
0.93(2.30-6.90)10.1±1.119.50±1.10(5.60-12.1)2.52±0.243.20±0.22(2.00-5.40)地鼠0.42±0.120.36±0.11(0.20-0.74)54.8±11.951.5±11.0(10.0-80.0)1.05±0.280.98±0.30(0.35-1.65)73.4±12.665.0±10.5(32.6-118)23.4±6.7420.8±5.64(12.5-26.0)4.85±0.454.36±0.50(1.80-5.30)128±
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