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- 保存条件:
4°C, protect from light
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
504-96-1
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥1991.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥650.0 |
| 规格: | 5 mg | 产品价格: | ¥1500.0 |
| 规格: | 10 mg | 产品价格: | ¥2250.0 |
| 规格: | 25 mg | 产品价格: | ¥3825.0 |
| 规格: | 50 mg | 产品价格: | ¥5738.0 |
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Neophytadiene
CAS No. : 504-96-1
MCE 国际站:Neophytadiene
产品活性:Neophytadiene 是一种二萜,能从 Turbinaria ornate 中提取到,具有抗炎、抗氧化和心脏保护作用。
研究领域:Others
作用靶点:Others
In Vitro: Neophytadiene has cytotoxic on RAW 264.7 cells with an IC50 of 50 μM.
Neophytadiene (50-100 μM; 30 min) successfully inhibits the NO production level and downregulates inducible nitric oxide synthase (iNOS) production in LPS (1 μg/mL)-induced RAW264.7 cells.
Neophytadiene (25-100 μM; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in LPS (1 μg/mL)-induced RAW264.7 cells.
In Vivo: Neophytadiene (50 mg/kg; p.o.; daily; for 7 days) shows dose-dependent reduction in the alanine aminotransferase (ALT) level.
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased IL-6 and 1L-10 levels and in heart tissue.
Neophytadiene (25-50 mg/kg; p.o.; daily; for 7 days) significantly reduces LPS (10 mg/kg)-increased PGE2 mRNA expression in heart tissue.
Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo.
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文献和实验,96小时细胞开始出现脱落死亡;反应器无血清全悬浮培养BHK21细胞48小时的细胞显微镜观察状态如图2,生长至96小时细胞密度可达5.4x106 cells/ml,活率维持在94%左右。从细胞数量比较,650L反应器培养一批的细胞数量相当于500~700个15 L转瓶培养的细胞总量。 1.4 病毒培养效果对比 两种不同培养工艺,细胞在满足活力要求的基础上,以同等条件分别接种FMDV病毒,取样测定病毒毒价。 结果表明,无血清悬浮培养的口蹄疫病毒毒价(TCID50和LD
474.01~522.59 3 509.4 50.96 472.96~545.84 4 498.4 52.63 460.76~536.04 5 494.9 29.51 473.80~516.00 6 °546.7 43.23
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