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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human C-C chemokine receptor type 5 (CCR5)
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
20μg
英文名称:
Recombinant Human C-C chemokine receptor type 5 (CCR5)品名简称:
Recombinant Human CCR5 protein货号:
CSB-CF004844HU规格:
20μg价格:
6240LC-MS/Western Blot:
/SDS-PAGE:
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.纯度:
Greater than 85% as determined by SDS-PAGE.内毒素:
Not test生物活性:
/基因名:
CCR5Uniprot No.:
P51681别名:
CHEMR13 (HIV-1 fusion coreceptor) (CD_antigen: CD195) (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CMKBR5)种属:
Homo sapiens (Human)蛋白长度:
Full Length来源:
in vitro E.coli expression system分子量:
43.9 kDa表达区域:
1-352aa氨基酸序列:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL蛋白标签:
N-terminal 10xHis-tagged产品提供形式:
Liquid or Lyophilized powder缓冲液:
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
3-7 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.功能2:
/文献:
4 "Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses." Kuhmann S.E., Platt E.J., Kozak S.L., Kabat D. J. Virol. 71:8642-8656(1997)研究领域:
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文献和实验)。 B.分泌细胞因子: 肿瘤坏死因子(TNF);IL-8和血小板活化因子(PAF)等。 生物学功能: A.阻止穿过上皮组织屏障的病原体的感染(第一道防线); B.对IgE抗体结合的抗原迅速发生应答,引起急性变态反应性炎症反应; C.抗寄生虫感染。 六、 其他细胞 嗜酸性粒细胞表达分子: 1.高亲和性FcεRⅠ; 2.细胞因子受体:如IL-5、CC趋化因子(chemokines,如MCP-3)受体。
)CD2分子 此分子亦称为LFA-2、Len-5或羊红细胞受体等名称。为55KD单体分子,属Ig基因超家族,亦为穿膜糖蛋白分子。可存在于成熟T细胞及胸腺细胞,亦可发现于NK细胞。 CD2分子是细胞间粘附分子,其配体分子称为白细胞功能相关抗原-3(LFA-3,CD58),为55-70KD糖蛋白分子。可广泛表达于造血细胞和非造血细胞。CD2分子与羊红细胞上LFA-3结合形成花环,称为E-花环,可用鉴定和分离人T细胞。 CD2也是信号传导分子,可使T细胞活化,它不依赖于TCR
Examples of Involvement in Disease CCR5 provides a signal for microbial induced production of IL-12 by CD8+ dendritic cells Regulation of tyrosine kinase activation and granule release through -arrestin by CXCR
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