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- 2026年07月07日
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- 文献和实验
- 技术资料
- 保存条件：
−20°C
- 保质期：
咨询
- 英文名：
Phospho-DRP1 (Ser637) Antibody
- 库存：
现货
- 供应商：
浙江羽翔生物科技有限公司
- 规格：
100 µl
Product Specifications
REACTIVITY R
SENSITIVITY Endogenous
MW (kDa) 78-82
SOURCE Rabbit
Application Key:
WB-Western Blotting IP-Immunoprecipitation
Species Cross-Reactivity Key:
R-Rat
Product Information
Product Usage Information
Application Dilution
Western Blotting 1:1000
Immunoprecipitation 1:100
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
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文献和实验Cancer cells surviving cisplatin chemotherapy increase stress-induced OMA1 activity and mitochondrial fragmentation
Melvin Li 1 2, Chenille A McCullum 3, Louis T A Rolle 3, Qin Ni 4 5, Zhuoxu Ge 4 5, Sean X Sun 4 5, Kenneth J Pienta 3 6, Sarah R Amend 3 6
Affiliations Expand
PMID: 41495249 PMCID: PMC12848309 DOI: 10.1038/s41598-025-33677-1
Abstract
Cancer is one of the leading causes of deaths worldwide. Once cancer cells acquire therapy resistance, they become the main driver of cancer lethality in patients. Thus, mechanisms of therapy resistance must be investigated to improve patient outcomes. Mitochondria are critical organelles in the cellular stress responses, undergoing dynamic morphological and functional changes in response to external stimuli. We and others have identified a chemotherapy-resistant cancer cell state where cells that survive treatment exhibit a dramatic increase in cell size and remain non-proliferative for weeks. In this study, we demonstrate that cancer cells that enter this resistant cell state in response to cisplatin increase OMA1 activity and decrease mitochondrial fusion and function to combat oxidative stress. These findings contribute to further understanding the role of the mitochondrial stress responses in therapy resistance in cancer and provide a potential therapeutic avenue to targeting cancer cells that enter this chemotherapy-resistant cell state.
Keywords: Cancer; Mitochondrial dynamics; Mitochondrial morphology; OMA1; OPA1; Oxidative stress.
【求助】于NF-KB 激活，P65磷酸化位点是ser536还是ser276?
伽利略 ............................... chenlydd 两者都有,蛋白磷酸化水平与其功能密切相关：检测其磷酸化水平可用抗磷酸化位点抗体检测。www.cellsignal.com公司有相应抗体出售。 P65磷酸化位点: regulates apoptosis: S536‑p regulates cell growth: S536‑p regulates cell
david9931 请问各位大侠，有没有订做过磷酸化的丝氨酸或磷酸化的苏氨酸抗体，哪家公司做的比较好，小弟想订做目的蛋白特异位点的丝氨酸、苏氨酸的磷酸化的抗体，帮忙给指点下，多谢啦 euthor_hsu 这种抗体定做很难。毕竟要的是抗一个特异的氨基酸的磷酸化位点。 就我所知cisbio有anti-phosphothronine 和anti-phosphotyrosine的抗体，PAb和MAb都有，但是没有anti
Using Phospho‐Motif Antibodies to Determine Kinase Substrates
the phosphorylation site; therefore, substrate?directed, phosphorylation?state?sensitive, motif?specific (?phospho?motif?) antibodies represent powerful tools to identify novel kinase substrates and to investigate mechanisms of substrate phosphorylation
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