- ￥4800
- Tanda
- 美国
- TD-26912
- 2025年10月20日
- IP, IHC and IF (Not applicable for WB since WB denatures the GTPase)
- Mouse
- 脊椎动物
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 免疫原：
Recombinant full length protein of active Rap1.
- 亚型：
lgG
- 形态：
液体
- 保存条件：
-20℃
- 克隆性：
单克隆
- 标记物：
FITC
- 适应物种：
脊椎动物
- 保质期：
24个月
- 抗原来源：
蛋白表达
- 目录编号：
TD-26912
- 级别：
科研级
- 库存：
88
- 供应商：
武汉天德
- 宿主：
Mouse
- 应用范围：
IP, IHC and IF (Not applicable for WB since WB denatures the GTPase)
- 浓度：
1mg/ml
- 靶点：
Rap1
- 抗体英文名：
Anti-Rap1-GTP Monoclonal Antibody
- 抗体名：
Rap1-GTP
- 规格：
30 μL
Rap1-GTP
| Cat. #: TD-26912 |
| Size: 30 µL |
| Gene Symbol: RAP1 |
| Description: Anti-Rap1-GTP Mouse Monoclonal Antibody |
| Background: Small GTPases are a super-family of cellular signaling regulators. Rap family members (Rap1A, Rap1B, Rap2A, Rap2B, and Rap2C) are Ras-like GTPases that regulate cell proliferation, differentiation, apoptosis and adhesion mechanisms. Rap1 (Ras-proximate-1) regulates apoptosis through interaction with two MAP3K effectors of the MEK/ERK MAP-kinase pathway, Raf-1 and B-Raf. Rap1 regulates cell adhesion mechanisms through effector molecules such as the integrins and cadherins. |
| Immunogen: Recombinant full length protein of active Rap1. |
| Applications: IP, IHC and IF (Not applicable for WB since WB denatures the GTPase) |
| Recommended Dilutions: IP: 1 µg for 1~2 mg total cellular proteins IHC, IF: 1:50-1:250 |
| Concentration: 1 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: IgG |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Anti-Rap1-GTP monoclonal antibody recognizes active Rap1 of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
| Immunoprecipitation/Western blot: Rap1 Activation Assay.Purified Rap1 proteins were immunoprecipitated after treated with GDP (lane 1) or GTPγS (lane 2). Immunoprecipitation was done with the anti-Rap1-GTP monoclonal antibody (Cat. No. TD-26912). Immunoblot was with an anti-Rap1 polyclonal antibody (Cat. No. ). |
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- 作者
- 内容
- 询问日期
文献和实验Rap1 and Integrin Inside-Out Signaling
In leukocytes, integrins play important roles in adhesive interactions with endothelium, antigen-presenting cells, and effector functions such as cytotoxicity. This chapter describes methods to study Ras proximity 1 (Rap1), a signaling
小GTP结合蛋白(small GTP binding protein)
细胞中有两类结构不同的GTP结合蛋白:一种是单体GTP结合蛋白( 也称单体GTPase), 含有一条多肽链, 即是小GTP结合蛋白；另一种即是参与信号转导的三体G蛋白。 小GTP结合蛋白是细胞内的一个大的蛋白家族, 它以两种状态存在: 同GTP结合时, 具活性状态; 同GDP结合, 则是非活性状态。小GTP结合蛋白的活性和非活性状态的转变取决于两种蛋白: 一种是鸟嘌呤核苷释放蛋白(guanine-nucleotide-releasing protein, GNRP
GTP结合蛋白(GTP binding protein, G蛋白)
与GTP或GDP结合的蛋白质,又叫鸟苷酸结合调节蛋白(guanine nucleotide-binding regulatory protein)。从组成上看,有单体G蛋白(一条多肽链)和多亚基G蛋白(多条多肽链组成)。G蛋白参与细胞的多种生命活动,如细胞通讯、核糖体与内质网的结合、小泡运输、蛋白质合成等。 G蛋白偶联系统中的G蛋白是由三个不同亚基组成的异源三体,三个亚基分别是α、β、γ, 总相对分子质量在100kDa左右, β亚基为36 kDa左右, γ亚基
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