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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
A synthetic peptide from the internal region of RET which includes the mutation of C634Y, human origin.
- 亚型:
lgG
- 形态:
液体
- 保存条件:
-20℃
- 克隆性:
单克隆
- 标记物:
FITC
- 适应物种:
脊椎动物
- 保质期:
24个月
- 抗原来源:
蛋白
- 目录编号:
TD-26146
- 级别:
科研级
- 库存:
999
- 供应商:
武汉天德
- 宿主:
Mouse
- 应用范围:
ELISA, WB, IHC
- 浓度:
0.5 mg/ml
- 靶点:
C634Y
- 抗体英文名:
Anti-RET (C634Y) mouse monoclonal antibody
- 抗体名:
RET (C634Y)
- 规格:
100 μL
RET(C634Y)
| Cat. #: TD-26146 |
| Gene Symbol: RET, PTC, CDHF12, CAHF16, HSCR1, MEN2A, MEN2B |
| Description: Anti-RET(C634Y) Mouse Monoclonal Antibody |
| Background: RET protein is encoded by the RET proto- oncogene. It is a receptor tyrosine kinase. RET loss of function mutations are associated with the development of Hirschsprung’s disease, while gain of function mutations are associated with development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasia type 2A and 2B, pheochromocytoma and parathyroid hyperplasia. |
| Immunogen: A synthetic peptide from the internal region of RET which includes the mutation of C634Y, human origin. |
| Applications: ELISA, WB, IHC |
| Recommended Dilutions: ELISA: 1:1000-1:2000 WB: 1:500-1:1000 IHC: 1:50-1:100 |
| Concentration: 0.5 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: IgG |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Recognizes C634Y mutant, but not wild type RET of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
Western blot:
|
Immunoprecipitation/Western blot:
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文献和实验kelizi 哪位大侠知道RET原癌基因的结构域,其相应的定位、功能? 以及相应蛋白在细胞的定位及功能?如何调节? 谢谢!如果有相应的文献资料更佳 woxingwosu http://www.genecards.org/cgi-bin/carddisp.pl?gene=RET&search=ret 应该比较全了,你在从里面的链接可以找到更多~~ kelizi
challenge. Rearrangements of the RET oncogene have been proposed as a marker for papillary thyroid cancer. In this chapter, methods for the analysis of the RET oncogene in laser microdissected papillary thyroid cancer tissue are described.
脂肪燃烧的指令从哪里来?Nature 揭示神经免疫互作如何与
脂肪和 MSCs 中均观察到了 Gdnf 的表达降低。此外,在纯化的 MSCs 中刺激 ADRB2 可导致 MSCs 来源的 Gdnf 增加,PDGFRA 阳性的内脏脂肪细胞与 GDNF 在空间上也存在共定位。图片来源:Nature前期的研究表明,GDNF 家族配体及其受体 GFRα 能够激活神经系统、肾脏和造血细胞亚群中的酪氨酸激酶受体 RET。研究人员也在内脏脂肪 ILC2s 中观察到较高水平的 RET。为了研究这种受体酪氨酸激酶在脂肪 ILC2s 中的作用,他们特异删除了造血细胞中的 Ret,结果发现
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