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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
A synthetic peptide from the internal region of EGFR which includes the mutation of N826S, human origin.
- 亚型:
lgG
- 形态:
液体
- 保存条件:
-20℃
- 克隆性:
单克隆
- 标记物:
FITC
- 适应物种:
脊椎动物
- 保质期:
24个月
- 抗原来源:
蛋白
- 目录编号:
TD-26116
- 级别:
科研级
- 库存:
999
- 供应商:
武汉天德
- 宿主:
Mouse
- 应用范围:
ELISA, WB, IF, IHC
- 浓度:
1mg/ml
- 靶点:
N826S
- 抗体英文名:
Anti EGFR(N826S) Mouse Monoclonal Antibody
- 抗体名:
EGFR(N826S)
- 规格:
100 μL
EGFR(N826S)
| Cat. #: TD-26116 |
| Gene Symbol: EGFR/Her1/Neu |
| Description: Anti-EGFR(N826S) Mouse Monoclonal Antibody |
| Background: EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR). |
| Immunogen: A synthetic peptide from the internal region of EGFR which includes the mutation of N826S, human origin. |
| Applications: ELISA, WB, IF, IHC |
| Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:500-1:2000 IHC: 1:50-1:100 |
| Concentration: 1 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: Recognizes EGFR(N826S), but not wild type EGFR protein from vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing. |
| Western blot:
Western blot analysis of recombinant EGFR(N826S) and wild type proteins.
Immunofluorescence:
Immunofluorescence of cells expressing EGFR proteins with Anti-EGFR(N826S) antibody. HEK293T cells were transfected with pCDNA3-GFP-EGFR (WT) plasmid (left column) or pCDNA3-GFP-EGFR(N826S) plasmid (right column), then fixed and stained with anti- EGFR(N826S) monoclonal antibody (Cat. #TD-26116). |
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文献和实验A. Meyer( 1926)提出的表示湿润度的物理量,并赋以 N/ S=降水量(毫米)/(饱和水蒸气张力 -实际水蒸汽张力)(毫米 Hg)的定义。通常以一年的数量为对象,分母实际上是饱和水蒸汽张力对于当地平均气温之比,乘以空气关系饱和差(从 100减去平均相对湿度,又以 100除所得商)来求出。如下:表所示与植物群落及土壤类型的分布状况颇相一致。
In order to highlight our understanding on ecosystems functioning and resource sharing/competition, either in artificial environment or agrosystems, according to changes in the climatic conditions, it is necessary to measure accurately
厦门大学的研究团队评估了 EGFR 作为三阴乳腺癌免疫治疗靶点的可能性,通过体内实验和体外实验的结果得出,EGFR CAR-T 细胞展示出对三阴乳腺癌细胞强大的杀伤效果和潜力,提出 EGFR CAR-T 可以进一步向临床方向进行探索,获益更多的患者。 三阴乳腺癌(TNBC)以其侵袭性强、复发快速和预后效果差而闻名。目前以嵌合抗原受体 T (CAR-T)细胞为首的免疫疗法,已经成为治疗 TNBC 的一种有效工具,而其中肿瘤特异性抗原的选择和 CAR 结构的设计成为 CAR-T 治疗的挑战。 中国
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