- ￥4800
- Tanda
- 美国
- TD-26352
- 2025年10月25日
- ELISA, WB, IHC
- Mouse
- 脊椎动物
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified CASP8 protein, human origin.
- 亚型：
lgG
- 形态：
液体
- 保存条件：
-20℃
- 克隆性：
单克隆
- 标记物：
FITC
- 适应物种：
脊椎动物
- 保质期：
24个月
- 抗原来源：
蛋白
- 目录编号：
TD-26352
- 级别：
科研级
- 库存：
999
- 供应商：
武汉天德
- 宿主：
Mouse
- 应用范围：
ELISA, WB, IHC
- 浓度：
1mg/ml
- 靶点：
CASP8; ALPS2B; CAP4; MACH; FLICE
- 抗体英文名：
Anti-CASP8 Mouse Monoclonal Antibody
- 抗体名：
CASP8
- 规格：
100 μL
CASP8
Catalog Number: TD-26352
Gene Symbol: CASP8; ALPS2B; CAP4; MACH; FLICE
Description: Anti-CASP8 Mouse Monoclonal Antibody
Background: The CASP8 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. A very rare genetic disorder of the immune system can also be caused by mutations in this gene.
Immunogen: Purified CASP8 protein, human origin.
Tested applications: ELISA, WB, IHC
Recommended dilutions:
ELISA: 1:1000-1:2000
WB: 1:500-1:1000
IHC: 1:50-1:100
Concentration: 1 mg/ml
Host: Mouse
Clonality: Monoclonal
Purity: Purified from ascites
Format: Liquid
Storage buffer:
Preservative: no
Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity: Recognizes CASP8 of vertebrates.
Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.
Western blot:
Western blot analysis of recombinant CASP8 proteins. Purified His-tagged CASP8 protein (268-435aa, 25KD) was blotted with anti-CASP8
monoclonal antibody (Cat. #TD-26352).
Immunofluorescence:
Immunofluorescence of cells expressing CASP8 proteins with anti-CASP8 antibody. HEK293T cells were transfected with pCDNA3-GFP-CASP8 (WT) plasmid, then fixed and stained with anti-CASP8 monoclonal antibody (Cat. #TD-26352).
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文献和实验-8 (casp8) 依赖性细胞死亡。 参考消息： https://www.science.org/doi/10.1126/science.abg5251
凋亡的三岔路口，这个通路把控！韩家淮院士/莫玮等揭示坏死性凋亡的新机制
发育过程中 caspase-8 蛋白 Thr265 位点磷酸化抑制其对坏死性凋亡的阻断作用 既然在体外 Thr265 位点磷酸化能够逆转 caspase-8 对坏死性凋亡的阻断作用，那在体内是否也有相同的结果呢？作者构建了 Casp8T265E/T265E 组成性磷酸化突变小鼠，发现纯合小鼠卵黄囊血管系统异常，胚胎致死。免疫荧光和免疫组化结果显示 Casp8T265E/T265E 突变小鼠中坏死性凋亡的标志物 pRIP3 和 pMLKL 显著上调。与此同时，Rip3 和 Mlkl 缺陷能够逆转
Protein Structural Domains: Definition and Prediction
). In the CASP8 experiment it was parsed into five domains (shown here in different shades); the domains were not linear in sequence and there were a number of domain extensions (or decorations). The orientation of the domains is complicated by the fact
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