Guanylyl Cyclase-Activating Pr

产品名称：Guanylyl Cyclase-Activating Protein 1 (GUCA1A) Antibody-Guanylyl Cyclase-Activating Protein 1 (GUCA1A) Antibody

产品货号：abx028514

产品规格：80ul#400ul

应用类型：WB, IHC

保存建议：Guanylyl Cyclase-Activating Protein 1 (GUCA1A) Antibody-Guanylyl Cyclase-Activating Protein 1 (GUCA1A) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：Guanylate cyclase-activating protein is a l Ca (2+) binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90% similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca (2+) binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.

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关键词：Guanylyl Cyclase-Activating Protein 1 (GUCA1A) Antibody，Guanylyl Cyclase-Activating Protein 1 (GUCA1A) Antibody，待更新