Interferon-Induced, Double-Str

产品名称：Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (EIF2AK2) Antibody-Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (EIF2AK2) Antibody

产品货号：abx025142

产品规格：80ul#400ul

应用类型：WB, IHC

保存建议：Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (EIF2AK2) Antibody-Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (EIF2AK2) Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：Interferon-induced, double-stranded RNA-activated protein kinase (PRKR) is a serine-threonine kinase. Activation by dsRNAs leads to autophosphorylation of PRKR and allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha), leading to the inhibition of protein synthesis. Human gamma-interferon (IFNG) mRNA exploits localized activation of PRKR in the cell to regulate its own translation. IFNG mRNA activates PRKR through a pseudoknot in its 5-prime untranslated region. The HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PRKR and the translation initiation factor EIF2-alpha, a target of PRKR. E2 inhibits the kinase activity of PRKR and blocks its inhibitory effect on protein synthesis and cell growth, which provides one mechanism by which HCV may circumvent the antiviral effect of interferon. PRKR, which is involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, also activates IKK and NFKB, thereby suppressing apoptosis. Apoptosis induced by live pathogenic gram-positive and gram-negative bacteria requirs both TLR4 and PRKR, possibly representing a major mechanism for pathogenic bacteria that use specific virulence factors to avoid detection and destruction by the innate immune system. Roles for PRKR activation in Huntington disease and Fanconi anemia have also been suggested.

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关键词：Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (EIF2AK2) Antibody，Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase (EIF2AK2) Antibody，待更新