Trx-Tag Antibody/Trx-Tag Antib

产品名称：Trx-Tag Antibody-Trx-Tag Antibody

产品货号：abx005591

产品规格：100ul#200ul

应用类型：WB

保存建议：Trx-Tag Antibody-Trx-Tag Antibody建议收到产品后，储存温度为-20°C。避免重复冻融

背景资料：Trx-Tag Antibody is a Mouse Monoclonal antibody against Trx-Tag. Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx has several biological functions. It acts as a hydrogen donor for ribonucleotide reductase, which is critical for DNA synthesis, and modulates the DNA-binding activity of several transcription factors, including NFκB, AP-1, p53, TFIIIC and glucocorticoid receptor. Trx also stimulates cell growth, is an inhibitor of apoptosis and plays a role in the protection against oxidative stress. Drugs that inhibit Trx have antitumor activity, suggesting that Trx is involved in a variety of human diseases, including cancer. Thioredoxin 2 (Trx-2) is a small redox protein that is localized to the mitochondria and is essential for cell viability, playing a crucial role in the scavenging of ROS in mitochondria and regulating the mitochondrial apoptosis signaling pathway. Trx reductases (TrxR1 and TrxR2) are ubiquitously expressed flavoproteins that catalyze the NADPH-dependent reduction of Trx as well as several other oxidized cellular components. Mammalian Trx reductases are a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. TrxR1 and TrxR2 are also involved in the prevention of oxidative stress. Inhibition of TrxR activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.

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Abbexa总部位于英国剑桥的剑桥科学园，是一家专业的全球抗体供应商和蛋白质供应商，致力于为生命科学、药物开发和生物技术领域的科学家和研究者提供最佳的客户体验和高质量的产品。产品涵盖一抗、二抗、蛋白质、ELISA试剂盒、酶以及其他用于研究的试剂盒和工具。无论您是进行学术研究，药物开发，疾病研究还是其它生物学研究，Abbexa的单克隆抗体，多克隆抗体，蛋白质和生物试剂均旨在促进您的研究。如果很难找到合适的抗体来满足您的需求，Abbexa还提供了定制蛋白质，肽和抗体的生产渠道。

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关键词：Trx-Tag Antibody，Trx-Tag Antibody，待更新