- ￥2550 - 4150
- Solarbio
- 北京
- K108726P
- 2025年07月16日
- WB IHC
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
A synthetic peptide of Human CASP8
- 亚型：
IgG
- 形态：
液体
- 保存条件：
低温
- 克隆性：
Polyclonal Antibody
- 标记物：
CASP8
- 适应物种：
Human
- 保质期：
标签为准
- 目录编号：
841
- 库存：
99
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB IHC
- 浓度：
咨询
- 抗体英文名：
Anti-CASP8 Polyclonal Antibody
- 抗体名：
CAP4;Casp-8;FLICE;MACH;MCH5;Caspase 8;CASP8;Caspase-8;caspase-8
- 规格：
50ul/100ul
| 规格： | 50ul | 产品价格： | ￥2550.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥4150.0 |
产品简介
| 英文名称 | Anti-CASP8 Polyclonal Antibody |
| 宿主 | Rabbit |
| 别名 | CAP4;Casp-8;FLICE;MACH;MCH5;Caspase 8;CASP8;Caspase-8;caspase-8 |
| 稀释比例 | WB 1:2000-5000. IHC 1:50-200. |
| 蛋白分子量 | 27/32/55kDa |
| Gene ID | 841 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG |
| 免疫原 | A synthetic peptide of Human CASP8 |
| 亚细胞定位 | Cytoplasm |
| Swiss Prot | Q14790 |
| 背景资料 | Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. |
| Public Immunogen Range | 360-410/479aa |
| 克隆类型 | Polyclonal Antibody |
| 交叉反应 | Human |
| 应用 | WB IHC |
| 规格 | 50ul 100ul |
实验图 
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文献和实验Polyclonal Antibody Production
, if desired this is best accomplished by Protein A Affinity Chromatography. 上一篇：make an Antibody against a Peptides 下一篇：Immunization Protocol for Monoclonal Antibody Production
Polyclonal Antibody Production
Polyclonal Antibody Production Very useful for rapid and simple generation of antibodies for western blots, ELISA assays, and immunoprecipitation. Rabbit Immunization Initial Preparation Your antigen
a simple ELISA method to detect human anti-antibody response.
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