- ￥480 - 1600
- Solarbio|ActivAb
- 北京
- K115916P
- 2025年08月22日
- WB;IHC
- Rabbit
- Human;Mouse
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- 详细信息
- 技术资料
- 免疫原：
Recombinant protein of human EXD2
- 亚型：
IgG
- 保存条件：
Store at -20℃. Avoid freeze / thaw cycles.
- 克隆性：
Polyclonal Antibody
- 标记物：
Biotin，Cy3，Cy3.5，Cy5，Cy5.5，Cy7，FITC，HRP，RBITC，Solar Fluor 350，Solar Fluor 405，Solar Fluor 488，Solar Fluor 532，Solar Fluor 555，Solar Fluor 568，Solar Fluor 594，Solar Fluor 633，Solar Fluor 640，Solar Fluor 647，Solar Fluor 660，Solar Fluor 680，Solar Fluor 750
- 适应物种：
Human;Mouse
- 抗原来源：
Recombinant protein of human EXD2
- 目录编号：
55218
- 级别：
实验级别
- 库存：
现询
- 供应商：
北京索莱宝科技有限公司
- 宿主：
Rabbit
- 应用范围：
WB;IHC
- 浓度：
WB 1:1000-3000.IHC 1:50-200.
- 靶点：
EXD2
- 抗体英文名：
Anti-EXD2 Polyclonal Antibody
- 抗体名：
核酸外切酶3’-5’结构域样2
- 规格：
20ul/100ul/50ul
| 规格： | 20ul | 产品价格： | ￥480.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1600.0 |
| 规格： | 50ul | 产品价格： | ￥960.0 |
| 基本信息 | |
| 英文名称 | Anti-EXD2 Polyclonal Antibody |
| 中文名称 | 核酸外切酶3’-5’结构域样2 |
| 宿主 | Rabbit |
| 克隆类型 | Polyclonal Antibody |
| 亚型 | IgG |
| 交叉反应 | Human;Mouse |
| 应用 | WB;IHC |
| 稀释比例 | WB 1:1000-3000.IHC 1:50-200. |
| 密度 | |
| 靶标 | EXD2 |
| 别名 | Exonuclease 3’-5’ domain-containing protein 2;EC:3.1.11.1;3’-5’ exoribonuclease EXD2;EC:3.1.13.-;EC:3.1.13.-;Exonuclease 3’-5’ domain-like-containing protein 2;C14orf114;EXDL2; |
| 背景说明 | Exonuclease that has both 3’-5’ exoribonuclease and exodeoxyribonuclease activities， depending on the divalent metal cation used as cofactor (PubMed:29335528， PubMed:31127291).In presence of Mg2+， only shows 3’-5’ exoribonuclease activity， while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn2+ (PubMed:29335528， PubMed:31127291).Acts as an exoribonuclease in mitochondrion， possibly by regulating ATP production and mitochondrial translation (PubMed:29335528).Also involved in the response to DNA damage (PubMed:26807646， PubMed:31255466).Acts as 3’-5’ exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073， PubMed:26807646).Plays a key role in controlling the initial steps of chromosomal break repair， it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3’-5’ exonuclease activity， which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646).Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression， thereby suppressing their degradation (PubMed:31255466). |
| Swiss Prot | Q9NVH0 |
| Gene ID | 55218 |
| 亚细胞定位 | Cytoplasm Nucleus |
| 免疫原 | Recombinant protein of human EXD2 |
| Public Immunogen Range | 101-400aa |
| 理论分子量 | 56/70kDa |
| 实际分子量 | 66kDa |
| EC | |
| 纯化方法 | Affinity purification |
| 储存液 | PBS with 50% Glycerol， 0.03% Proclin300， 0.5% BSA， pH 7.3. |
| 储存条件 | Store at -20℃. Avoid freeze / thaw cycles. |
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K115916P Anti-EXD2 Polyclonal Antibody
￥480 - 1600
