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Anti-Glutamine Synthetase, clo

ne GS-6; 100 μg
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  • 询价
  • MAB302
  • 2025年07月15日
  • ELISA;Western Blotting
  • Mouse
  • Human;Mouse;Rat;Sheep
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 应用范围：

      ELISA;Western Blotting

    • 宿主：

      Mouse

    • 适应物种：

      Human;Mouse;Rat;Sheep

    • 抗原来源：

      0

    • 库存：

      大量

    • 是否单克隆：

      1

    • 规格：

      100 μg

    Species Reactivity Key Applications Host Format Antibody Type
    H, M, R, Sh ELISA, IH, IH(P), WB Mouse Purified Monoclonal Antibody
    Description:
    Anti-Glutamine Synthetase, clone GS-6
    Background Information:
    Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. It is found in astrocytes as an octamer of identical 45 kDa subunits. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.
    Clone:
    GS-6
    Specificity:
    Reacts strongly with a single band on Western blots of sheep brain and rat brain. Glutamine synthetase, an enzyme that catalyzes the amination of glutamic acid to form glutamine, is found in mammals as an octamer of eight identical 45 kDa subunits. Glutamine synthetase activity has been shown to be a useful marker of astrocytes and an important differentiation feature in retina. Glutamine synthetase is also considered to be a key enzyme in the recycling of the neurotransmitter glutamate.
    Key Applications:
    • ELISA
    • Immunohistochemistry
    • Immunohistochemistry (Paraffin)
    • Western Blotting
    Application Notes:
    Western blot: 1:1,000-1:5,000

    Immunohistochemistry on rat brain

    ELISA

    Optimal working dilutions must be determined by end user.
    Species Reactivity:
    • Human
    • Mouse
    • Rat
    • Sheep
    Isotype:
    IgG2a
    Immunogen:
    Glutamine synthetase purified from sheep brain.
    Molecular Weight:
    45 kDa
    Control:
    Rat brain tissue, rat brain cytosolic fraction extract
    Presentation:
    Purified immunoglobulin. Liquid in buffer containing 50% glycerol, BSA and 0.09% sodium azide.
    Storage Conditions:
    Maintain antibody at 2–8°C in undiluted aliquots for up to 12 months. Avoid repeated freeze-thaw cycles.
    Gene Symbol:
    • GLUL
    • GLNS
    Antibody Category:
    Neuroscience
    Antibody Sub-Category:
    Neurofilament & Neuron Metabolism
    Usage Statement:
    Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    Trade Name:
    Chemicon (Millipore)
    Format:
    Purified
    Host:
    Mouse
    Concentration:
    1 mg/mL
    Antibody Type:
    Monoclonal Antibody

    更多产品技术资讯，请访问密理博中国博客：http://blog.milliporechina.com

    Glutamine synthetase purified from sheep brain. 详细描述见链接：http://www.millipore.com/catalogue/item/MAB302

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    图标文献和实验
    相关实验

    • 谷氨酰氨合成酶 glutamine synthetase

      　　缩写为 GS。为在 ATP的存在下使氨与谷氨酸结合生成谷氨酰胺的酶， EC． 6． 3． 1． 2． L-谷氨酸 氨 ATPL- 谷氨酰胺 ADP Pi反应机制很复杂，要经过酶蛋白与γ -谷氨酰磷酸的中间体。与谷氨酰胺合成反应不同的是可将γ -谷氨酰基转移于适当的受体，具有如羟胺的γ -谷氨酰基转移酶的活性。广泛分布于微生物和高等动植物中，除了可供给谷氨酰氨外，还有与谷氨酸合成酶偶联向α -氨基酸供给氨基的重要功能。大肠杆菌和枯草菌的酶是由分子量为 5万的单一的 12个亚基

    • Anti-P-CREB

      policeman.4. Put the extract into an eppendorf and boil for 5 min., cool on ice.5. Load onto 10% SDS-PAGE. I usually load about 1/5 of the lysate from a 60 mm dish. This is about 100 μg protein for PC12 cells.6. After electrophoresis, electrotransfer

    • Generation of Heavy and Light Chains (Chimeric Antibodies)

      describes the cloning and expression of chimeric antibodies using Lonza’s “double-gene vectors” (Lonza Biologics’ Glutamine Synthetase (GS) gene expression system) in mammalian cells.

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