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文献和实验Synchronizing Protein Transport in the Secretory Pathway
., Gordon, D.E., Franch‐Marro, X., Peden, A.A., Vincent, J.P., and Munro, S. 2010. A genome‐wide RNA interference screen identifies two novel components of the metazoan secretory pathway. EMBO J. 29:304‐314
v468 Chapter 9 自身启动子报告基因验证转录靶点
of the canonical Wnt signaling pathway.However, b-catenin does not itself bind DNA, but functions via interaction with T-cell factor (TCF)/lymphoid-enhancing factor (LEF) transcription factors. These proteins contain a high-mobility group(HMG) box that binds DNA
does not result in b-cateninnuclear accumulation (10) . These data indicate that the insulin/Akt signaling pathway does not affect the b-catenin destructioncomplex, but only affects a pool of GSK-3 that is involved in theregulation of glycogen synthase
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