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文献和实验Quality Control of Raw Materials
chemicals whenever possible (these are labeled BP, USP, or EuPh and many are available from Merck, Lutterworth, UK) and to require the supplier to send a certificate of analysis with all raw materials. Any supplier who cannot provide a certificate
Protocols of In Vitro Protein Covalent Binding Studies in Liver
, or formation of an immunogenic species. The toxicological consequences of exposure to such reactive intermediates range from mild inflammation to organ failure, anaphylaxis, and death. At Merck Research Laboratories, the potential of drug candidates to bind
/budding is preferentially visualized. The purpose of the assay is to test the function of different molecules in the docking/fusion or sorting/budding processes. Therefore, inhibitors or activators of different molecules should be tested (see Step 37
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