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文献和实验v468 Chapter 9 自身启动子报告基因验证转录靶点
of the canonical Wnt signaling pathway.However, b-catenin does not itself bind DNA, but functions via interaction with T-cell factor (TCF)/lymphoid-enhancing factor (LEF) transcription factors. These proteins contain a high-mobility group(HMG) box that binds DNA
does not result in b-cateninnuclear accumulation (10) . These data indicate that the insulin/Akt signaling pathway does not affect the b-catenin destructioncomplex, but only affects a pool of GSK-3 that is involved in theregulation of glycogen synthase
cation. One pathway is to repair the cleaved site via nonhomologous endjoining (NHEJ) pathway, which applies only to the DSBs as SSNsare thought to be unable to induce NHEJ pathway. During NHEJmediatedrepair, insertion/deletion (indels
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