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文献和实验Preparation of Polysaccharide-Conjugate Vaccines
T-cells were found to recognize (glyco) lipids in a CD1-restricted way, γδT-cells were shown to respond to non-proteinaceous microbial ligands (that may include carbohydrates) in a virtually MHC-unrestricted way ( 5 ). The findings of T-cell
白细胞分化抗原及其功能 CTLA-4 属CD28家族成员。CTLA-4为细胞毒性T细胞相关分子,又称CDl52,为同源二聚体,胞膜外区也 有1个IgSF的V样区。 与T细胞识别、黏附和活化有关CD分子的结构 CTLA-4分子结构保守,人和小鼠的胞质区完全相同。CTLA-4与CD28分子有31%同源性。静止T细胞不表达CTLA-4,T细胞活化后CTLA-4呈诱导性表达。V样区高度保守的MYPPPY基序
AntibodyDrug Conjugate (ADC) Clinical Pipeline: A Review
Biological therapies play an increasing role in cancer treatment, although the number of naked antibodies showing clinical efficacy as single agent remains limited. One way to enhance therapeutic potential of antibodies is to conjugate
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