- 询价
- CC1000
- 2025年07月14日
- Inhibits Activity/Function
- 0
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- 详细信息
- 技术资料
- 应用范围：
Inhibits Activity/Function
- 宿主：
0
- 抗原来源：
0
- 库存：
大量
- 是否单克隆：
0
- 规格：
1 mg
Description:
GM6001 MMP Inhibitor
Trade Name:
Chemicon (Millipore)
Product Overview:
Specificity: GM6001 MMP inhibitor, also known as Ilomastat or N-[(2R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan methylamide, is a potent inhibitor of collagenases. Molecular weight: 388.47
Reported Ki values are as follows (see Galardy Ref):·
Human MMP-1 (Fibroblast collagenase): 0.4 nM·
Human MMP-3 (Stromelysin): 27 nM·
Human MMP-2 (72 kDa gelatinase): 0.5 nM·
Human MMP-8 (Neutrophil collagenase): 0.1 nM·
Human MMP-9 (92 kDa gelatinase): 0.2 nM
Typical working dilution for use in cultured cells is 10-25 μM. GM6001 will precipitate from aqueous solutions exceeding 100μM. Aqueous dilutions should be performed using low salt buffers to prevent precipitation of GM6001 from solution (Recommended dilution buffer: 50 mM Tris pH7.5, 150 mM NaCl, and 20 mM CaCl2.2H20). It is recommended that the concentration of GM6001 in aqueous working solutions is determined upon dilution and confirmed prior to each use. Relative concentrations of GM6001 in aqueous solutions may be determined by measuring the absorbance of the solution (tyrosine) at 280 nm.
Reported Ki values are as follows (see Galardy Ref):·
Human MMP-1 (Fibroblast collagenase): 0.4 nM·
Human MMP-3 (Stromelysin): 27 nM·
Human MMP-2 (72 kDa gelatinase): 0.5 nM·
Human MMP-8 (Neutrophil collagenase): 0.1 nM·
Human MMP-9 (92 kDa gelatinase): 0.2 nM
Typical working dilution for use in cultured cells is 10-25 μM. GM6001 will precipitate from aqueous solutions exceeding 100μM. Aqueous dilutions should be performed using low salt buffers to prevent precipitation of GM6001 from solution (Recommended dilution buffer: 50 mM Tris pH7.5, 150 mM NaCl, and 20 mM CaCl2.2H20). It is recommended that the concentration of GM6001 in aqueous working solutions is determined upon dilution and confirmed prior to each use. Relative concentrations of GM6001 in aqueous solutions may be determined by measuring the absorbance of the solution (tyrosine) at 280 nm.
Key Applications:
Inhibits Activity/Function
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Presentation:
Provided at 1 mg/mL (2.5 mM) in DMSO.
Storage Conditions:
Maintain frozen at -20°C in DMSO for up to 12 months. Avoid storage once diluted into aqueous solutions.
Inhibitor Type:
Protease Inhibitors
Gene Symbol:
- MMP1
- CLG
- MMP-1
- CLGN
- EC 3.4.24.7 [Contains: 22 kDa interstitial collagenase
- 27 kDa interstitial collagenase].
Protein or Enzyme Type:
Inhibitors
Concentration:
1 mg/mL (2.5 mM) in DMSO
更多产品技术资讯，请访问密理博中国博客：http://blog.milliporechina.com
详细描述见链接：http://www.millipore.com/catalogue/item/CC1000
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GM6001 MMP Inhibitor; 1 mg
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