- 询价
- CC1010
- 2026年01月15日
- Inhibits Activity/Function
- 0
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Inhibits Activity/Function
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- 规格：
10 mg
Product Images
Dose Response for GM6001 on MMP-2 Activity
Reported Ki values are as follows (see Galardy Ref):·
Human MMP-1 (Fibroblast collagenase): 0.4 nM·
Human MMP-3 (Stromelysin): 27 nM·
Human MMP-2 (72 kDa gelatinase): 0.5 nM·
Human MMP-8 (Neutrophil collagenase): 0.1 nM·
Human MMP-9 (92 kDa gelatinase): 0.2 nM
Typical working dilution for use in cultured cells is 10-25 μM. GM6001 will precipitate from aqueous solutions exceeding 100μM. Aqueous dilutions should be performed using low salt buffers to prevent precipitation of GM6001 from solution (Recommended dilution buffer: 50 mM Tris pH7.5, 150 mM NaCl, and 20 mM CaCl2.2H20). It is recommended that the concentration of GM6001 in aqueous working solutions is determined upon dilution and confirmed prior to each use. Additional Application information:
Use in vivo
Typical dosage for GM6001 in animals is 50-100mg/kg body weight. It is generally administered IP every day or every other day. It is thought to cross the blood brain barrier since studies have shown it effectiveness in MS models.
If delivered by I.V. the half life in an animal is approximate an hour so it will have to be administered quite often. Thus the preferred way is to deliver the drug by I.P as a suspension in water or saline. The half life does not change but because it is dissolving in the animal's system slowly, administration is not done as frequently. It has to be redelivered every other day or so. It can also be delivered subcutaneously in a saline suspension. The drug will precipitate as stay as a mass within the tissue, but surprisingly enough does get into the animal system to be effective.
Solubility
Soluble up to at least 400mg/ml in DMSO. It can then be diluted in water and must be mixed very quickly to avoid precipitation.
Stability
GM6001 in DMSO or Water at a concentration of 1mM (0.1mM is preferred) decomposes at the rate of 1% per month at 4%. At 37C this increases to 1% per day. At -20 it is quite stable and as a solid very highly stable
Low salt buffers are recommended as diluents to reduce precipitation. Diluted solutions should never be frozen.
Concentration of the stock solution should be periodically determined by absorbance at 280nm.
- MMP1
- CLG
- MMP-1
- CLGN
- EC 3.4.24.7 [Contains: 22 kDa interstitial collagenase
- 27 kDa interstitial collagenase].
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文献和实验株和hOB的生长分为细胞增殖、骨基质成熟、骨基质矿化阶段，且I型胶原、BGP、MMP-1、TIMP-1基因表达及ALP活性呈时间特异性。二、人成骨肉瘤MG-63细胞株和成人成骨细胞基质金属蛋白酶及其抑制因子的表达目的：观察人成骨肉瘤MG-63细胞株和正常成人成骨细胞（hOB）基质金属蛋白酶（MMPs）和基质金属蛋白酶抑制因子（TIMPs）表达的类型。方法：MMPs和TIMPs mRNA表达用RT-PCR检测。结果：人成骨肉瘤MG-63细胞株和hOB均表达MMP-1、MMP-2、MMP-7、MMP-10
(Table 1 ). The enzymatic activity of MMP family members is controlled by a group of inhibitor proteins known as the Tissue Inhibitors of Metalloproteinases (TIMPs), which consist of four family members (Table 2 ). Whereas all four TIMPs can inhibit
HIV病毒Pol基因部分 人胰岛素样生长因子-Ⅱ 人血小板生成素(hTPO)N 端 ，C端 人表皮生长因子 人血小板生成素 REF-1 ＣＤ59 N-Ras 人胰腺激肽释放酶基因KIKI RECK MMP9 iNOS eNOS GAPDH(人或犬) P16 cyp2c9 乙型脑炎病毒SA14-14-2株prM基因 CYP1A2/G-2964A CYP1A2/C734A HNMT/C314T HNMT/A595G CYP2D6*10 β1－
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