- ￥485
- Sigma-Aldrich
- 进口
- 83580-5G
- 2025年09月10日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
常温
- 保质期：
根据瓶身LOT号查询
- 英文名：
Reserpine
- 库存：
有现货
- 供应商：
浙江羽翔生物科技有限公司
- CAS号：
50-55-5
- 规格：
5G
属性
产品名称
利血平, crystallized, ≥99.0% (HPLC)
方案
≥99.0% (HPLC)
表单
solid
旋光性
[α]20/D −123±3°, c = 1% in chloroform
质量
crystallized
mp
~265 °C (dec.)
SMILES字符串
CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
InChI
1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
InChI key
QEVHRUUCFGRFIF-MDEJGZGSSA-N
基因信息
human ... SLC18A2(6571)
一般描述
应用
生化/生理作用
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文献和实验Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies.
Intercellular biomolecule transfer (ICBT) between malignant and benign cells is a major driver of tumor growth, resistance to anticancer therapies, and therapy-triggered metastatic disease. Here we characterized cholesterol 25-hydroxylase (CH25H) as a key genetic suppressor of ICBT between malignant and endothelial cells (ECs) and of ICBT-driven angiopoietin-2-dependent activation of ECs, stimulation of intratumoral angiogenesis, and tumor growth. Human CH25H was downregulated in the ECs from patients with colorectal cancer and the low levels of stromal CH25H were associated with a poor disease outcome. Knockout of endothelial CH25H stimulated angiogenesis and tumor growth in mice. Pharmacologic inhibition of ICBT by reserpine compensated for CH25H loss, elicited angiostatic effects (alone or combined with sunitinib), augmented the therapeutic effect of radio-/chemotherapy, and prevented metastatic disease induced by these regimens. We propose inhibiting ICBT to improve the overall efficacy of anticancer therapies and limit their prometastatic side effects.
CHAPS Insoluble Floating Fraction Preparation
7.5, 50 mM NaCl, 2 mM EDTA). They were finally resuspended in TEBP (TEB plus various protease inhibitors: 1x PIC I and 1x PIC II) to 2 x 108 /ml. CHAPS powder was added at 20 mg/ml. After gentle mixing, the lysed cells were kept on ice for 3-5
新兰) 1g/5g 120/400 Amresco分装 B1026★ Alloxan（四氧嘧啶） 10g 350 Sigma分装 B1027 Amido Black 10B (氨基黑) 5g/10g/100ml 80/120/50
. Monitor the gel temperature to ensure it stays at 60℃ or below (preferably 50-55℃). N.B: Allowing the gel temperature to exceed 60℃ for extended periods of time will cause the hydrolysis of urea in the gel. 12) After electrophoresis is complete, combs
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