Anti-Dopamine Transporter Rabb

Anti-Dopamine Transporter; 100 µg

Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT), a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. DAT is also the target of several “DAT-blockers” including amphetamines and cocaine. These chemicals inhibit the action of DAT and, to a lesser extent, the other monoamine transporters, but their effects are mediated by separate mechanisms.

• DA transporter
• dopamine transporter
• solute carrier family 6 (neurotransmitter transporter, dopamine),member 3
• variable number tandem repeat (VNTR)

Cat. AB2231 recognizes the N-terminus of the reduced and non reduced forms of DAT.

Western Blotting

Rabbit

Rat and Mouse. Reactivity with other species has not been determined.

Synthetic Linear Peptide

N-terminus

~ 50 – 80 kDa
Reduced form at approx 50 kDa and Non-reduced form at approx. 80 kDa

Rat Brain Lysate.

Purified Antibody in PBS with 0.1% NaN3

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.

• DAT
• DAT 1

Routinelyevaluated by western blot on rat brain lysate.

Neuroscience

Ion Channels & Transporters

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Purified

Rabbit

1 mg/mL

Polyclonal Antibody