(±)5-HEPE

(±)5-HEPE是由EPA的非酶促氧化产生的。它含有等量的5(S)-HEPE和5(R)-HEPE。(±)5-HEPE的生物活性可能是由其中一种异构体介导的，在哺乳动物系统中最常见的是5(S)异构体。EPA可以在人类和牛中性粒细胞以及人类嗜酸性粒细胞中代谢为5-HEPE，后者进一步代谢为5-oxoEPE和LTB5。EPA的5系列代谢物，即5-HEPE、5-oxoEPE和LTB5，与花生四烯酸衍生的代谢物相比，其生物效应显著降低。(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.分子式C20H30O3分子量318.5CC/C=C\C/C=C\C/C=C\C/C=C\C=C/C(O)CCCC(=O)O