Propantheline (bromide)

一种抗胆碱能药物；抑制乙酰胆碱诱发的豚鼠离体回肠收缩，降低大鼠迷走神经刺激的胃收缩强度；以5mg/kg皮下剂量给药时，可增加Shay大鼠胃内pH值并预防幽门结扎诱发的胃溃疡形成；抑制慢性胃瘘恒河猴模型中基础和五肽胃泌素刺激的胃分泌，但不抑制组胺刺激的胃分泌。An anticholinergic agent; inhibits acetylcholine-induced contraction of isolated guinea pig ileum and reduces intensity of vagal-stimulated gastric contractions in rats; increases gastric pH and prevents pyloric ligature-induced gastric ulcer formation in Shay rats when administered at a dose of 5 mg/kg, s.c.; inhibits basal and pentagastrin-, but not histamine-, stimulated gastric secretion in a rhesus monkey model of chronic gastric fistula.