Annonacin

来自A.muricata的线粒体复合物I抑制剂（IC50=54.8nM）；诱导大鼠的ATP耗竭、tau病理和多巴胺能细胞死亡（EC50分别为134、44.1和60.8nM）；降低细胞存活率（MCF-7细胞中的ED50=0.31µM）；以每天50mg/kg的剂量减小裸鼠中的MCF-7异种移植肿瘤大小。A mitochondrial complex I inhibitor from A. muricata (IC50 = 54.8 nM); induces ATP depletion, tau pathologies, and dopaminergic cell death in rats (EC50s = 134, 44.1, and 60.8 nM, respectively); reduces cell survival (ED50 = 0.31 µM in MCF-7 cells); decreases MCF-7 xenograft tumor size in nude mice at a dose of 50 mg/kg per day.