4μ8C

IRE1α抑制剂；抑制IRE1α与Xbp1mRNA的剪接(IC50=6.8µM)；降低IRE1α和Xbp1下游的Erdj4基因表达(IC50=3.4µM)；不阻断IRE1α自身磷酸化；降低CD4+T细胞中的IL-4产生；降低LPS刺激的TNF-α和IL-6mRNA表达和蛋白质分泌的增加。An IRE1α inhibitor; inhibits IRE1α splicing of Xbp1 mRNA (IC50 = 6.8 µM); reduces Erdj4 gene expression downstream of IRE1α and Xbp1 (IC50 = 3.4 µM); does not block IRE1α autophosphorylation; reduces IL-4 production in CD4+ T cells; reduces LPS-stimulated increases in TNF-α and IL-6 mRNA expression and protein secretion .