Cyclothiazide

一种苯并噻二嗪，可作为AMPA受体的增效剂，正向调节其对谷氨酸的反应(EC50=3.8µM)；也是GABAA受体的负向调节剂，可逆性抑制诱发和自发的抑制性突触后电流(IC50=58µM)。A benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 µM); also a negative modulator of GABAA receptors, reversibly inhibiting both evoked and spontaneous inhibitory postsynaptic currents (IC50 = 58 µM).