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- 2025年07月12日
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长效β2-AR激动剂（β2-、β1-和β3-AR的EC50分别为0.79、63.1和9.4nM）；抑制豚鼠离体气管条带的电刺激收缩（EC50=2.51nM）；以0.12-12mM的浓度通过气雾剂给药，抑制豚鼠组胺诱发的支气管收缩。A long-acting β2-AR agonist (EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively); inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM); inhibits histamine-induced bronchoconstriction in guinea pigs via aerosol administration at 0.12-12 mM.
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文献和实验相关实验
Site-Directed Mutagenesis in the Investigation of -Adrenoreceptor Exosite
, such as metaproterenol, fenoterol, and terbutaline; and saligenins, such as salbutamol and salmeterol. Of these, salmeterol, a highly lipophilic derivative of the partial agonist, salbutamol, represents the latest long-acting generation of β-agonists, with a duration
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Salmeterol (xinafoate)
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