15(R),19(R)-hydroxy Prostaglan

19(R)-羟基化前列腺素在某些哺乳动物物种（尤其是灵长类动物）的精液中以µg/ml的浓度存在。在人类中，这些化合物主要属于PGE系列，羟基立体化学为15(S)、19(R)。19(R)-羟基化前列腺素也存在于有袋动物的精浆中，其中1和2系列的F型化合物占主导地位。这些19-羟基化前列腺素的15(R)-羟基差向异构体是C-15处的逆异构体或“非天然”异构体。19(R)-羟基化前列腺素的生物学作用尚不明确。在F系列中，19(R)-羟基化与某些测定中受体介导的生物活性的显著丧失有关。19(R)-Hydroxylated prostaglandins occur in µg/ml concentrations in the semen of certain mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R). 19(R)-Hydroxylated prostaglandins are also found in the seminal plasma of marsupials, where F-type compounds of the 1 and 2-series predominate. The 15(R)-hydroxy epimer of these 19-hydroxylated prostaglandins is the inverse or “unnatural” isomer at C-15. The biological role of 19(R)-hydroxylated prostaglandins is not well established. In the F-series, 19(R)-hydroxylation is associated with a significant loss of receptor-mediated biological activity in some assays.