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一种聚酮合酶离子载体抗生素；与单价和双价阳离子结合；对E. tenella在0.01和0.1 µg/ml浓度下有效；在125 ppm的饲料中减少了实验性感染E. tenella、E. maxima、E. necatrix、E. brunetti或E. acervulina的雏鸡的胃肠损伤程度；已在地下水中发现。A polyketide-synthase ionophore antibiotic; binds to monovalent and divalent cations; active against E. tenella at 0.01 and 0.1 µg/ml; reduces the severity of gastrointestinal lesions in chicks experimentally infected with E. tenella, E. maxima, E. necatrix, E. brunetti, or E. acervulina at 125 ppm in the feed; has been found in groundwater.
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文献和实验相关实验
Synthesis of Monensin Derivatives and Their Effect on the Activity of Ricin A-Chain Immunotoxins
can be potentiated in vitro by lysosomotropic amines (e.g., NH4 Cl, chloroquine, methylamine, amantadine), ionophores (e.g., monensin, nigericin, lasalocid), or lysosomal enzyme inhibitors (e.g., leupeptin, pepstatin) (8 -13 ).
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Lasalocid
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