KMN-80

EP4的选择性强效激动剂，在功能测定中，其IC50值为3nM（而EP3为1.4μM，所有其他前列腺素受体为>10μM），EC50值为0.19nM；体外诱导年轻和老年大鼠的骨髓干细胞分化为成骨细胞（EC50分别为20和153nM）；在体内大鼠颅颌面重建模型中修复颅骨缺损，并在大鼠门牙牙槽模型中促进骨形成。A selective, potent agonist of EP4 with an IC50 value of 3 nM (versus 1.4 μM for EP3 and > 10 μM for all other prostanoid receptors) and an EC50 value of 0.19 nM in functional assays; induces the differentiation of bone marrow stem cells from both young and aged rats into osteoblasts in vitro (EC50s = 20 and 153 nM, respectively); repairs calvarial defects in an in vivo rat craniomaxillofacial reconstruction model and promotes bone formation in a rat incisor tooth socket model.