ML-180

LRH-1的反向激动剂(IC50=3.7µM)，最大抑制效果为64%；对相关的SF1转录激活因子无活性；改变结合珠蛋白、SAA1和SAA4的表达，诱导ER阴性MDA-MB-231乳腺癌细胞死亡，并抑制StAR启动子(IC50=2.05µM)。An inverse agonist of LRH-1 (IC50 = 3.7 µM) with maximum efficacy of 64% repression; inactive at the related SF1 transcriptional activator; alters the expression of haptoglobin, SAA1, and SAA4, induces the death of ER negative MDA-MB-231 breast cancer cells, and inhibits the StAR promoter (IC50 = 2.05 µM).