Metyrapone

11β-羟化酶抑制剂(IC50=7.83µM)；诱导大鼠肝微粒体中Cyp1a1和Cyp3a4的表达，并抑制绵羊肝微粒体中11β-HSD1的活性；以150mg/kg的剂量抑制大鼠缺氧缺血引起的血浆皮质酮水平升高和癫痫发作；降低嗜酒大鼠的乙醇消耗量。An 11β-hydroxylase inhibitor (IC50 = 7.83 µM); induces Cyp1a1 and Cyp3a4 expression in rat hepatic microsomes and inhibits the activity of 11β-HSD1 in sheep liver microsomes; suppresses hypoxia-ischemia-induced increases in plasma corticosterone levels and seizures in rats at 150 mg/kg; reduces ethanol consumption in alcohol high-preferring rats.