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文献和实验Calpastatin (the Endogenous Calpain Inhibitor) and Membrane Protein Degradation in Cell Fusion
Cell membrane fusion is a ubiquitous cellular process, mediating such phenomena as fertilization, muscle development, certain viral infections, and giant cell formation from macrophages. For membrane fusion to occur, the cell
of its attack on membrane-bound cytoskeletal protein targets (7 ). The zymographic assay also assesses calpain activity independently of the effects of the endogenous calpain inhibitor, calpastatin. Acute CNS injury such as TBI can also importantly affect brain
The Role of Calpain in Neurofilament Protein Degradation Associated With Spinal Cord Injury
in glial cells, both calpain isoforms share similar substrate specificities and are inhibited by an endogenous inhibitor, calpastatin (2 ). A broad range of proteins in the CNS, including cytoskeletal and myelin proteins such as neurofilament
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