IκBζ Polyclonal Antibody

抗原：对应于小鼠IkBζ氨基酸684-699和285-298的合成肽；宿主：兔；交叉反应性：(+)小鼠IkBζ；应用：WB；IκBζ优先与NF-κB亚基p50而不是p65结合，重组IκBζ蛋白抑制p65/p50异二聚体和p50/p50同二聚体的DNA结合。在培养的B淋巴细胞和单核细胞/巨噬细胞中，TLR配体、IL-1和IL-6刺激可上调IκBζ转录，但在T淋巴细胞、成纤维细胞和内皮细胞中，这种上调作用微弱。Antigen: synthetic peptide corresponding to mouse IkBζ amino acids 684-699 and 285-298; Host: rabbit; Cross Reactivity: (+) mouse IkBζ; Application(s): WB; IκBζ preferentially associates with the NF-κB subunit p50 rather than p65 and recombinant IκBζ proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer. Transcription of IκBζ is upregulated by stimulation with TLR ligands, IL-1, and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells.