Bleomycin (sulfate)

Distribution of Bleomycin in a Rat Model

Bleomycin has, in the years of developing electrochemotherapy (ECT), proven to be an extremely potent drug for this cancer treatment modality and is also the most frequently applied chemical agent. It is of importance to investigate

Metabolic Labeling with Sulfate

of proteins make it possible to determine where a protein normally resides or to follow its transport through the cell. One such modification is addition of sulfate either to tyrosine residues or to carbohydrate side chains. Labeling studies with [35 S

博莱霉素（争光霉素）bleomycin

　　 轮枝链霉菌（ Streptomyces verticillus）产生的抗肿瘤的抗菌物质，由梅沢浜夫等（ 1965）分离出来的。可分为 A、 B两大类， A类还可细分为 5种。在化学结构上，是含 2-3个硫原子的多肽与铜螫合。抗肿瘤作用是基于它可抑制 DNA合成，抑制作用包括切断 DNA和抑制 DNA多聚酶的合成．据称对鳞状上皮细胞癌尤其有效。