IRAK-4 Polyclonal Antibody

抗原：对应于小鼠IRAK-4氨基酸38-54和120-136混合物的合成肽；宿主：兔；交叉反应性：(+)人和小鼠IRAK-4；应用：IP和WB；IRAK4可充当IRAK-1的上游激活剂，对LPS激活TLR很重要。缺乏IRAK-4的小鼠对致死剂量的LPS具有抗性，并且对病毒和细菌攻击的反应也严重受损Antigen: synthetic peptide corresponding to a mixture of mouse IRAK-4 amino acids 38-54 and 120-136; Host: rabbit; Cross Reactivity: (+) human and mouse IRAK-4; Applications: IP and WB; IRAK4 may act as an upstream activator of IRAK-1 and is important for LPS activation of TLRs. Mice lacking IRAK-4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges.