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- Cayman
- 12006-10 mg
- 2025年07月13日
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抑制PKCδ(IC50=3μM)、CAM激酶III和多种蛋白激酶，包括PRAK和MAPKAP-K2（IC50s分别为1.9和5μM）；通过靶向mTORC1上游的信号级联刺激自噬Inhibits PKCδ (IC50 = 3 μM), CAM kinase III, and a wide range of protein kinases, including PRAK and MAPKAP-K2 (IC50s = 1.9 and 5 μM, respectively); stimulates autophagy by targeting a signaling cascade upstream of mTORC1.
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文献和实验相关实验
Critical Appraisal of the MTT Assay in the Presence of Rottlerin and Uncouplers
Rottlerin is a natural product isolated from Mallotus philippinensis . This polyphenolic compound, originally described as a selective inhibitor of PKCδ, can inhibit many other PKC-unrelated kinases and has a number of biological
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Rottlerin
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