Stevioside (hydrate)

天然无热量甜味剂；浓度为1µM时可增加小鼠胰岛分离物中葡萄糖刺激的胰岛素分泌；浓度为1mM时可减少LPS刺激的THP-1细胞中TNF-α和IL-1β产生的增加，但也可诱导未受刺激的THP-1细胞中TNF-α和IL-1β的产生；浓度为0.03g/kg时可降低GK2型糖尿病大鼠的收缩压；减少TPA诱导的小鼠耳部水肿（ID50=291.6µg/耳）A natural non-caloric sweetener; increases glucose-stimulated insulin secretion in isolated mouse pancreatic islets at 1 µM; reduces LPS-stimulated increases in TNF-α and IL-1β production in THP-1 cells, but also induces TNF-α and IL-1β production in unstimulated THP-1 cells at 1 mM; decreases systolic blood pressure in GK type 2 diabetic rats at 0.03 g/kg; reduces TPA-induced ear edema in mice (ID50 = 291.6 µg/ear).